药物性肝病患者髓过氧化物酶基因多态性分析（基础医学范文）.docVIP

药物性肝病患者髓过氧化物酶基因多态性分析（基础医学范文） 文档信息 主题： 关于“医学心理学”中“内科学”的参考范文。 属性： F-00NZ94，doc格式，正文5400字。质优实惠，欢迎下载！ 适用： 作为文章写作的参考文献，解决如何写好实用应用文、正确编写文案格式、内容摘取等相关工作。 作者： 佚名 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 搞要 1 关键字：药物性肝病；髓过氧化物酶；基因多态性 2 1 资料与方法 3 2 结果 5 3 讨论 6 [参考文献] 7 论文原创声明（模板） 8 论文致谢（模板） 9 正文 药物性肝病患者髓过氧化物酶基因多态性分析（基础医学范文） 搞要 摘要：目的探讨髓过氧化物酶（MPO）基因多态性与药物性肝病（DILI）之间的关系。方法病例采用对照分析的方法，方便收集37例药物性肝病患者和30例健康对照者外周血标本，提取DNA进行MPO-463G/A多态性检测。结果MP0-463GG、GA和AA3种基因型的频率在DILI组中分别为%、%和%，在对照组中分别为%、%和%；将携带MP0-463GA和AA型者合并后与携带MPO-463GG型相比较，患DILI的风险显著增高，相对于G等位基因，携带A等位基因的个体患DILI的风险显著降低，说明MP0-463G/A多态性与DILI的发生有关。结论髓过氧化物酶基因多态性与药物性肝病易感性之间存在相关性，值得进一步研究 关键字：药物性肝病；髓过氧化物酶；基因多态性 [中图分类号] +7 [文献标识码] A [文章编号] 1674-0742（2016）05（b）-0079-02 [Abstract] Objective To discuss the correlation between the myeloperoxidase gene polymorphism and drug-induced liver disease. Methods The peripheral blood samples of 37 cases of patients with drug-induced liver disease and 30 healthy control people were collected according to the case control analysis method， and the MPO-463G/A polymorphism detection was carried out by extracting DNA. Results The genotype frequency of MP0-463 GG， GA and AA was respectively %， % and % in the DILI group and %， % and % in the control group； the risk of suffering from DILI in patients with MP0-463 GA and AA obviously increased compared with that of the patients with MPO-463 GG， the risk of suffering from DILI of individuals with A allele obviously decreased compared with that of the individuals with G allele， which indicated that MP0-463 G/A polymorphism was correlated with the occurrence of the DILI. Conclusion Myeloperoxidase gene polymorphism has a correlation with the susceptibility of drug-induced liver disease， which is worth further research. [Key words] Drug-induced liver disease； Myeloperoxidase； Gene polymorphism 药物性肝病（Drug-induced liver disease，DILI）是指由于临床治疗、营养或药物滥用所引起的肝细胞损伤性疾病，其发病机制复杂，主要与药物、个体差异和药物与机体的相互作用等方面相关，近几年关于诊断DILI没有特异性的诊断标准[1]。髓过氧化物酶（Myeloperoxidase MPO