哮喘发病参与的细胞图示.pptxVIP

Airway pathology in asthmaEpithelial damagevasodilatationHypertrophy of smooth muscle(contraction of smooth mucle)Thickened basement membraneMucus plugMucus hyper-secretion LABA哮喘治疗药物细胞水平的作用病毒?腺苷运动粉/烟雾感觉神经激活支气管痉挛血浆渗出肥大细胞抗原嗜酸性细胞巨噬细胞气道高反应性病毒?T-淋巴细胞吸入激素Barnes Nice 2001许多的细胞及组分在哮喘疾病中起作用单核细胞adhesion moleculesIL-8CPLA2树突状细胞GRO-?IL-16ICAM-1IL-11NOFGF巨噬细胞MCP-1G-CSFIL-12SCFCGRPcollagenaseLTC-4ICAM-1GM-CSFLTB-4IGF-IeotaxinVCAM-1IFN-?MCP-2TNF-?PDGF0 speciesIL-1IL-2PGE2 IL-12IFN-?RANTESGM-CSFGM-CSFPGF2?EAFIL-1TNF-?IL-1?ICAM-1/3IL-1?MIP-1?15-LT5IL-6TGF-?TNF-?TXA2iNOSPGE2MCP-3IL-1IL-3IL-6CD8COX2IL-8IL-8PGE