药理学教学课件：Adrenoceptor agonists.ppt

* DA * ISOP * ISOP * ISOP 1 Heart Cardiac contractility↑ Heart rate↑ Cardiac conduction↑ Small Dose Large Dose Skin、Mucosa Contraction Contraction Skeletal Muscle Contraction Contraction Visceral： Kidney Diastole * Contraction Mesentery Diastole * Contraction Peripheral Resistance 2 Blood Vessels Small Dose Large Dose S P DP or Pulse Pressure 3 Blood Pressure 【 Clinical Applications】 1、All kinds of shock, especially suitable for shock with oliguria or anuria； 2、Renal Failure Small dose Combinated with diuretics 3、Congestive Heart Failure Often combinated with vascular dilation drugs 【 Adverse Reaction】 1. Lighter at therapeutic dose，such as nausea、vomiting etc 2. Large dose will cause arrhythmia，reduction of renal blood flow，fall of renal function etc. A. Immidiatly as the condition appears： Reduce the drug dose in time or stop . B. Use phentolamine if necessary. Ephedrine 【Characteristics】 Slow、Mild、Lasting CNS stimulating effects and rapid tolerance 【The In Vivo Process】 1 Easy to be absorbed by p.o. 2 Can pass the BBB. 3 Prototype is excreted by kidney slowly，and the effects last longly. 【Pharmacological Effect】 (+) α 1 、α2、β1、β 2 receptor Promote the release of NA 1 Heart： Cardiac contractility↑ The change of heart rate is not obvious Blood Vessels： BP rise Slow、Mild、Lasting 2 Bronchial Smooth Muscle Relax 3 Central Nervous System Excited 【Clinical Applications】 1 Preventing and