PET头颈癌-ComparisonofPET,CT,MRI课件讲解.pptxVIP

Positron Emission Tomography;「luE、e I;FDG PET in Normal;FDG accumulation in cancer cells ? Action of glucose transporter proteins. ? Highly active hexokinase bound to tumor mitochondria helps to trap FDG into cell. ? Relative hypoxia in tumor masses which activate the anaerobic glycolytic pathway. ? The increased glucose uptake is due to the need for nucleic acid synthesis and, therefore, is directly related to the tumors tendency to grow. ? FDG uptake is strongly related to the number of viable tumor cells, although not directly regulated by the need for DNA synthesis.;PET in Oncology;Health