Feline infectious peritonitis猫传染性腹膜炎.pdfVIP

Feline infectious peritonitis 猫传染性腹膜炎猫传染性腹膜炎 Katrin Hartmann ProfProf. DrDr. medmed. vetvet., DrDr. habilhabil., DiplDipl. ECVIMECVIM-CACA Ludwig Maximilian University Munich, Germany „Jefffferson“ • BSH, 11 months, male neutered • 英国短毛猫，11个月，雄性去势 • presenting complaints 主诉 - more quiiett siince 33 weekks, now very lleththargiic 持续3周过于安静，现在嗜睡 - intermittendintermittend feverfever, weightweight lossloss, thoracicthoracic effusioneffusion 间歇热，体重下降，胸腔渗出 Jefferson WhatWhat isis FIP?FIP? 什么是FIP? feline infectious peritonitis (FIP) 猫传染性腹膜炎猫传染性腹膜炎 WhatWhat isis FIP?FIP? 什么是FIP? feline infectious peritonitis (FIP) causedcaused byby aa felinefeline coronaviruscoronavirus (FCoV)(FCoV) 猫传染性腹膜炎是由猫冠状病毒引起的 • feline enteral coronavirus猫肠道冠状病毒(FECV) • FIP virus 猫传染性腹膜炎病毒猫传染性腹膜炎病毒(FIPV)(FIPV) Herrewegh et al., 1995 HowHow doesdoes FIPFIP develop?develop? FIP如何发生？ by chance mutation 变异 deletiondeletion inin thethe 3C3C oror 7B7B genegene 3C或7B基因的缺失 HHerreweghh ett all., VVennema ett all., not at the same location移位 ability to bind to ribosomes in macrophages 能结合到巨能结合到巨噬细胞核糖体细胞核糖体上 replication in macrophages 在巨噬细胞中进行复制在巨噬细胞中进行复制 = FIP 猫传染性腹膜炎 WhyWhy dodo onlyonly somesome catscats developdevelop FIP?FIP? 为什么仅有一部分猫会发传染性腹膜炎? increasedincreased intestinalintestinal virusvirus replicationreplication 肠道病毒复制的增强 = increased risk of mutation增加了病毒变异的风险 factors influencing replication影响复制的因素 -young age 年龄较小 - geneticgenetic predispositionpredisposition (feline(feline leleukockocytete antigenantigen complecomplex?)?) 遗传因素（猫白细胞抗