内容文本案例讲稿sci写作session11editing of3manuscripts10917.pptxVIP

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内容文本案例讲稿sci写作session11editing of3manuscripts10917.pptx

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Session 11 Editing of Three Manuscripts Part 1, Toxicology Letters 2014; 225:275-84;Original: p53/miR-34c axis mediated cell cycle is involved in cell malignant transformation induced by benzo[a]pyrene Concerns: Stacked words (x2); word missing. Final: Cell cycle changes mediated by the p53/miR-34c axis are involved in the malignant transformation of cells by benzo[a]pyrene ;Original: Identification of aberrant microRNA (miRNA) expression during chemical carcinogen-induced cell transformation will lead to a better understanding of the substantial role of miRNAs in cancer development. Concerns: Lack of precision; unnecessary words; use of ‘role.’ Final: Characterization of aberrant microRNA (miRNA) expression during carcinogen-induced cell transformation will lead to a better understanding of the function of miRNAs in cancer development.;Original: The results showed that chronic exposure to BaP induced malignant transformation of cells. In BaP transformed-cells, there were increased levels of mutant p53 (mt-p53), and greater down-expression of wild-type p53 (wt-p53) and phosphorylated p53 (p-p53). Concerns: Too many words; repeated words; awkward statement, ‘greater down-expression.’ Final: Chronic exposure to BaP induced malignant transformation of cells, in which there were increased levels of mutant p53 (mt-p53) and reduced expression of wild-type p53 (wt-p53) and phosphorylated p53 (p-p53). ;Original: Thus, we have reported that p53/miR-34c axis mediated cell cycle regulation is involved in the malignant transformation of cells induced by BaP. Concerns: Too many words; stacked words; unnecessary word. Final: Thus, changes in the cell cycle mediated by the p53/miR-34c axis are involved in the malignant transformation of cells induced by BaP.;Original: Growing evidence suggests that miRNAs might function as oncogenes or tumor suppressor genes, and abnormal expression of miRNAs contributes to the development of human cancers. Concerns: Too many words; two weak words