会后肺癌免疫治疗进展.pptxVIP

会后肺癌免疫治疗进展第1页/共68页会计学第2页/共68页TCR or CAR genetic engineeringT cell cloningCD40肿瘤免疫治疗方式Peptide vaccineDC vaccineGenetic vaccineCD137IL-2IFNIL-15IL-21OX40CTLA-4PD-1Active immunotherapyAdoptive cell transferimmunotherapy第3页/共68页癌症抵御免疫调节抑制检查点第4页/共68页CTLA-4 和 PD-1/L1 检查点阻断Priming phase (lymph node)Effector phase (peripheral tissue)T-cell migrationCancer cellDendritic cellT cellT cellMHCMHCTCRTCRB7CD28PD-1T cellDendritic cellCancercellT cellPD-L1B7CTLA-4Ribas A. N Engl J Med. 2012;366:2517-2519.第5页/共68页第6页/共68页Slide 3Presented By Marina Garassino at 2015 ASCO Annual Meeting第7页/共68页肿瘤药物的发展策略新单药后线治疗二线治