教程成果遗传12绪论.pptxVIP

Good Morning;Medical Genetics and Embryonic Development 医学遗传与胚胎发育;课程简介;课程内容;授课教师;课程成绩;使用教材;陈竺 主编，傅松滨、张灼华、顾鸣敏副主编《医学遗传学》 (第3版)定稿会，人卫社，2014;参考书目;参考网址;Medical Genetics;All medicine is genetics ? --- Mckusick VA.; Why Molecular Biology?; Why Embryology（胚胎学）?;;Human Variation and Heredity — we are all 99.9% the same, DNA-wise! ;Genetics;Chapter 1 Genetics in Medicine;GENETIC BASIS OF HEALTH AND DISEASES;Genetic disorders: the disorders are caused by deficiency of genetic structure, they can be present at birth or manifest themselves late in life. They are usually familial but may be sporadic.;BRIEF HISTORY OF MEDICAL GENETICS;Gregor Mendel (1822-1884) was the founder of modern genetics;History of Medical Genetics ;Year;HGP;Chapter 1 Genetics in Medicine;;From Chromosome to DNA;;Goals of the HGP ;The international Human Genome Sequencing Consortium;;Four Maps;Genetic map;Physical Map ;Two methods for sequencing the human genome;Template and Sequencing Room;Standard of Complete sequence;Human Genome Project Goals and Completion Dates (2003);IHGSC. Finishing the euchromatic sequence of the human genome. Nature, 2004, 431: 931-945;Protein-coding genes;Encyclopedia of the Human Genome;Proposed project ;Human Genome Project in China;On August 28, 2001, Jiang Ze-min met scientists to participate in the International Conference on the Human Genome.;Comparative Genomics;Genome Comparisons;;Functional genomics;Methods for functional Genomics;Genome diversity occurs between different population and different individuals Help to understand human origins, evolution and migration Help to clarify the individuals in drug metabolism and effects of the genetic basis of differences to promote the discovery of new drugs to achieve individualized therapy. ;Size and frequency of major categories of genetic variants. Different sized genetic variants as a function of frequency are shown. Overall, single nucleotide polymorphisms (SNPs) occur at a higher frequency and ca