课件汇总2014物理药学intermolecular forces and substance phase.pptxVIP

Intermolecular Forces PhaseIntramolecular ForcesCovalent BondIonic BondCoordinate BondJames BondIntermolecular ForcesVan der Waals ForceIonic InteractionHydrogen BondHydrophobic InteractionLead to CompoundsLead to ComplexesWhat are Intermolecular Forces?Example?Benzene DNA-polymer complexIntermolecular Forces in Pharmacy and BiotechnologyPhysical states of pharmaceutical agentsGases, liquids or solids rely on intermolecular forcesAssociation of drugs and excipientsDrug stabilizersSolubilization enhancersDrug carriersPowder flow property and comprecibilityCohesion between particles and viscosity of powdersSurface tension and drug coatingHydrophobic-hydrophilic interactionStability of dispersed systemsPreventing emulsion flocculationIntermolecular Forces in Pharmacy and BiotechnologyDrug actionDrugs bind to receptors non-covalentlyDrugs prohibit enzymes non-covalentlyAntisense DNA bind to mRNA ionicallyBio-adhesionHydrogen bond between drug carriers and mucosalBio-signal recognitionComplexation to receptors; extend circulation timeMolecular assembly and nanotechnologyNano-fabrication = molecular assembly = intermolecular interactionIntermolecular Forces and Nano-fabricationManufacture processMechanical engineeringSubmicron fabricationNanometer fabricationAccuracy and scale 10 mm 200 nm 100 nmPhysical principles usedMechanical cuttingLaser cuttingMolecular assemblyTypes of Intermolecular ForcesCohesion and AdhesionAAAttraction between same moleculesBBABAttraction between different moleculesBA△H = 2HAB – (HA + HB)If △H = 0, apparent interaction between A and B = 0. If △H 0, A and B are mixable. If △H 0, Types of Intermolecular Forcesvan der Waals ForcesDipole-dipole interactionDipole-induced dipole interaction Induced dipole-induced dipole interactionIon-dipole interaction ion-induced dipole interaction+-+-1~7 Kcal/mol+-1~3 Kcal/mol0.5~1 Kcal/molR4N+ :NR3 K+I- I-I K+ + I3-+-+-Types of Intermolecular ForcesHydrophobic InteractionAttraction between water molecu