医学假说栏目.docxVIP

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  • 2021-11-04 发布于天津
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PAGE 5 “医学假说”栏目 炎调方抑制肺泡上皮细胞凋亡减轻肺水肿机制假说 欧阳洋,施 荣(上海中医药大学附属曙光医院,上海 201203) 【摘 要】脓毒症易引起急性肺损伤/急性呼吸窘迫综合征(ALI/ARDS),肺水肿是其主要病理生理。脓毒症导致肺泡上皮细胞(AEC)受损是肺水肿形成及加重的关键。AEC的钠水转运系统维持肺泡内外液体平衡。AEC凋亡增加,是脓毒症致ALI/ARDS肺泡上皮细胞损伤的主要表现;以Caspase8为中心的死亡受体通路调控AEC凋亡。我们前期研究发现,炎调方能减少LPS导致的AECII凋亡,减轻ALI/ARDS大鼠肺水肿。本文旨在就一步阐述炎调方作用AEC减轻脓毒症致ALI/ARDS肺水肿的可能机制。 【关键词】急性肺损伤;肺泡上皮细胞;肺水肿;炎调方 【中图分类号】R563 【文献标志码】A A hypothesis of mechanism of Yantiao Prescription inhibiting apoptosis of alveolar epithelial cells to reduce pulmonary edema OUYANG Yang, SHI Rong Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China 【Abstract】Sepsis is liable to lead to acute lung injury/acute respiratory distress syndrome (ALI/ARDS). Pulmonary edema is the main pathophysiological manifestation of ALI/ARDS. Sodium-water transport system maintains fluid balance inside and outside the alveoli. The damage of alveolar epithelial cells (AECs) caused by sepsis is the key to the formation and aggravation of pulmonary edema. The increase of AEC apoptosis is the main manifestation of ALI/ARDS AEC damage caused by sepsis. AEC apoptosis is regulated through caspase 8-centered death receptor pathway. Yantiao Prescription can reduce the apoptosis of AEC = 2 \* ROMANII induced by LPS, alleviate pulmonary edema and protect lung tissue in ALI/ARDS rats. This study aims at elucidating the possible mechanism underlying the effect of Yantiao Prescription on AECs for alleviating pulmonary edema induced by sepsis. 【Keywords】acute lung injury; alveolar epithelial cells; pulmonary edema; Yantiao Prescription 基金项目:国家自然科学基金81974539);上海市临床重点专科项目(shslczdzk04402) 通信作者:施 荣。 TelE-mail:doctorshi@126.com 作者简介:欧阳洋。学士,主治医师。研究方向:中西医结合治疗急危重症。TelE-mail:ssdouyang@163.com 脓毒症易导致急性肺损伤/急性呼吸窘迫综合征(acute lung injury/acute respiratory distress syndrome,ALI/ARDS),肺水肿是主要病理生理,治疗存难点。肺泡上皮细胞(alveolar epithelial cells,AEC)上的钠水转运系统维持肺泡内外液体平衡。II型肺泡上皮细胞(type II alveolar epithelial cell

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