木犀草素制剂的研究进展.pdfVIP

中草药 2021 年 2 月 第 52 卷 第 3 期 Chinese Traditional and Herbal Drugs 2021 February Vol. 52 No. 3 ·873 · 木犀草素制剂的研究进展 1 2 1 1 1 2* 2* 姚薛超 ，宁洪鑫 ，黄 欢 ，黄龙岳 ，王世博 ，李亮 ，侯文彬 1. 天津中医药大学，天津 301617 2. 北京协和医学院 中国医学科学院放射医学研究所，天津市放射医学与分子核医学重点实验室，天津 300192 摘 要：木犀草素是一种具有多种药理活性的黄酮类化合物，但因其水溶性差及生物利用度低等限制了其临床应用。微粒给 药系统、固体分散体、包合物、磷脂复合物、水凝胶等制剂技术的应用可提高木犀草素的生物利用度，综述了木犀草素制剂 的研究进展，并阐述了其在细胞和动物实验中的应用，旨在促进其制剂开发及临床应用。 关键词：木犀草素；制剂；溶解性；生物利用度；微粒给药系统；固体分散体；包合物；磷脂复合物；水凝胶 中图分类号：R283.3 文献标志码：A 文章编号：0253 - 2670(2021)03 - 0873 - 10 DOI: 10.7501/j.issn.0253-2670.2021.03.032 Research progress on pharmaceutical preparation of luteolin 1 2 1 1 1 2 YAO Xue-chao , NING Hong-xin , HUANG Huan , HUANG Long-yue , WANG Shi-bo , LI Yi-liang , HOU Wen-bin2 1. Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China 2. Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Peking Union Medical College Chinese Academy of Medical Sciences, Tianjin 300192, China Abstract: Luteolin is a flavonoid compound with a variety of pharmacological activities, but its clinical application is limited due to its poor water solubility and low bioavailability. The application of microparticle drug delivery system, solid dispersion, inclusion complex, phospholipid complex, aquogel, and other preparation technique can improve the bioavailability of luteolin. Research progress on pharmaceutical preparation of luteolin and their applications in cell and animal experiments are reviewed in this article, in order to promote its preparation development and clinical application. Key words: luteolin; pharmaceutical preparation; solubility; bioavailability; microparticle drug delive