多功能纳米药物及核酸载体.docxVIP

多功能纳米药物及核酸载体 帅心涛* 中山大学化学与化学工程学院、中山医学院，邮编 ：510275;电话：020-传真：020- E mail: shuaixt@mail.sysu.edu.c n 基于高分子的药物及基因传输纳米载体是目前非常热门的研究领域。我们制备了多种用于药物和基 因或siRNA传输的聚合物纳米载体，通过在载体结构中引入分子靶向配体例如单链抗体、叶酸等获得了 对T细胞、肿瘤细胞等的主动靶向传输。同时，通过在纳米载体内负载核磁共振显像（ MRI ）试剂，可 以无创伤地检测药物和基因的靶向化输送效率。 Figure 1. Formation of MRI-visible targeting polyplex. 参考文献 T. M. Allen, P. R. Cullis, Science 2004, 303, 1818-1821. N. Nasongkla, X. Shuai, H. Ai, J. Gao, Angew. Chem. Int. Ed., 2004, 43, 6323-6327. G. Chen, W. Chen, X. Shuai et al, Biomaterials , 2009,30, 1962-1970. io-inspired synthesis and self-assembly of unique functional inorganic nanostructures, nanocomposites and their applications Shu-Ho ng Yu* Divisi on of Nano materials and Chemistry, Hefei Nati onal Laboratory for Physical Sciences at Microscale,Departme nt of Chemistry, Un iversity of Scie nee and Techn ology of Chi na, Hefei 230026, Tel.: +86-551-3603040;Fax:+86-551-3603040, China. E-mail: shyu@ustc.edu.cn Developme nt of new methodologies for syn thesis and self-assembly of unique functional nano structures and nano composites has bee n of sig ni fica nce to access new materials with unique function alities. Herein, we will report several facile syn thetic protocols for on e-pot con trolled syn thesis of several kinds of unique inorganic nano materials and hybrids un der mild soluti on con diti on s, in which simple orga nic molecules, surfacta nt or low molecular weight polymers have bee n used. The high quality nan obuildi ng blocks we discussed in clude ultrath in nano wires, nan opiates, and magn etic nan oparticles, new hybrid semic on duct ing nan obelts/nano wires, con duct ing nano cables and nano tubes, and carb on-based nano structures. Especially, we report that periodic ordered mesostructures of hydrophilic ultrath in nano wires can be produced by Lan gmuir-Blodgett tech niq ue. The mesostructures of ultrathin Te nano wire films show reversibly switched photoelectric properties. In additi on, a series of lay