多伦多病童医院脑干胶质瘤PPT课件2.ppt

Pediatric High Grade Astrocytoma and Histone Mutations Me H3F3A replication-independent histone 3 variant 3.3 two critical positions within the histone tail -K27M, G34R HIST1H3B/C Replication-dependent histone 3 variant 3.1 K27M only Location and frequency of Histone 3 mutations in pediatric HGG H3K27M is a midline disease H3G34R/V is a hemispheric disease Hemispheric Thalamic Pontine (DIPG) 20% H3.3K27M H3.3G34R/V 65% 50% 15% H3.1K27M 50% Spinal cord CONCLUSIONS Pediatric DIPGs are one of the main causes of brain tumor death in children After decades of clinical trials, largely based on prot