辅酶一(NAD)与老年化疾病.ppt

Age-related diseases and cancer Age-related diseases COENZYME I CONTENTS A. NAD biosynthetic pathways and metabolism B. NAD consuming enzymes in health and disease C. Age-related diseases and cancer D. Mechanisms of NAD Precursors in humans and animal models E. NAD and the hallmarks of aging A. NAD biosynthetic pathways and metabolism NAD biosynthetic pathways and metabolism Eric Verdin. (2015). Special Section 350（6265）: 1208-1213. NAD biosynthetic pathways and metabolism in different cellular compartments. B. NAD consuming enzymes in health and disease NAD consuming enzymes in health and disease E F. Fang,. (2017). NAD+: a key metabolic regulator with great therapeutic potential: 1120-1143. NAD availability can influence the activity of three groups of master regulator enzymes the sirtuins, the PARPs and cyclic ADP-ribose synthases. Each group of enzymes regulate many biological processes and can thus couple changes in NAD levels with a wide range of physiological responses. C. Age-related diseases and cancer 1980s 1930s …… Age-related diseases and cancer could be the consequence of a decline in NAD+ concentrations Amanda Garrido (2017). Trend in cancer 181: 181-199. Age-related diseases and cancer Metabolic syndrome including cardiovascular disorders, type 2 diabetes and obesity, Neurodegenerative diseases such as Alzheimer and Parkinsondiseases, arthritis, and osteoporosis, and cancer are some of the diseases that commonly affect human health during aging. D. Benefits and mechanisms of NAD precursors in humans and animal models Benefits and mechanisms of NAD precursors in humans and animal models GSultani. (2017). Trends in Molecular Medicine23（10）: 900-918 Benefits and mechanisms of NAD precursors in humans and animal models GSultani. (2017). Trends in Molecular Medicine23（10）: 900-918 Benefits and mechanisms of NAD precursors in humans and animal models GSultani. (2017). Trends in Molecular Medicine23（10）: 900-918 E. NAD and the hallmarks of aging NA