关于甘草锌颗粒联合米诺环素胶囊治疗寻常痤疮的临床观察.docVIP

关于甘草锌颗粒联合米诺环素胶囊治疗寻常痤疮的临床观察 文档信息 属性： Doc-03D0LM，doc格式，正文6058字。质优实惠，欢迎下载！ 说明： 作为医药学资料、临床医学资料的写作参考资料，提供解决怎么写及格式等相关问题。 适用： 作为文章写作的参考文献，解决如何写好实用应用文、正确编写文案格式、内容摘取等相关工作。 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：关于甘草锌颗粒联合米诺环素胶囊治疗寻常痤疮的临床观察 1 1 资料与方法 3 (1)口服维A酸类药物停药时间 3 3 讨论 5 文2：金花消痤丸联合氯霉素酊治疗寻常性的治疗效果 6 1 资料与方法 6 3 讨论 8 参考文摘引言： 9 原创性声明（模板） 10 文章致谢（模板） 11 正文 关于甘草锌颗粒联合米诺环素胶囊治疗寻常痤疮的临床观察 文1：关于甘草锌颗粒联合米诺环素胶囊治疗寻常痤疮的临床观察 [Abstract] Objective To observe the effects and safety of Licofzine granu1es and minocycline in acne A randomized， controlled c1inica1 study was performed in 168 patients with acne patients were pided into two treatment group and the control group were orally given the combination of minocycline capsule and Licofzine granu1es or minocycline capsule singly， respectively. Simultaneously， 1% clindamycin phosphate gel was topically efficacy and side effects were evaluated after the six-week Compared with those in the control group， the cure rate and total effective rate in the treatment group were significantly higher(χ2=，P=;χ2=，P=).The patients whose conditio were not improved after the treatment were those with the grading IV. All the patients did not developed abnormal liver and renal functio only a few hadsome mild advee effects such as nausea， such as headache and facial edema， which spontaneously disappeared after stopping the Compared with the single use of minocycline， the combination of Licofzin zinc granules and minocycline showed a better clinical efficacy without obvious side effects in acne vulgaris。 [Key words] Licorzinc granules; Acne vulgaris; Minocycline 痤疮是一种发生于毛囊皮脂腺的慢性炎症性疾病，青春期发病率高，而且患病人数呈逐年增加的趋势。本病临床表现多形性，有粉刺、丘疹、脓疱、囊肿、结节，严重者遗留永久性、虫蚀状瘢痕，影响患者容貌，往往给患者及家庭造成经济和精神负担。 根据《中国痤疮治疗指南》，痤疮治疗的主要作用环节是抑制皮脂分泌、调节毛囊皮脂腺管口上皮角化和减轻局部炎症反应[1]。根据患者病情，给予口服或外用抗生素、维甲酸类药物等治疗。由于疗程较长，长期系统使用药物有肝脏损害等副作用，而抗生素长期口服容易诱导痤疮丙酸杆菌耐药[2]。甘草锌颗粒有抗炎、调节上皮角化和减少皮脂分泌的作用，而米诺环素是抗菌作用最强的四环素类抗生素，而且发生痤疮丙酸杆菌耐药率最低，被推荐用于治疗中重度寻常痤疮炎症性损害的一线类抗生素[1]。为了解两药联合使用在寻常痤疮治疗中的疗效，本科在2008年12