感冒药中对乙酰氨基酚的解析电喷雾质谱快检分析.docVIP

感冒药中对乙酰氨基酚的解析电喷雾质谱快检分析 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：感冒药中对乙酰氨基酚的解析电喷雾质谱快检分析 1 1、 实验部分 3 2、 结果与讨论 5 3、 结论 8 文2：高效液相色谱法测定仔花感冒胶囊中对乙酰氨基酚的含量 9 1 仪器与试药 9 2 方法与结果 10 3 讨论 12 参考文摘引言： 12 原创性声明（模板） 14 文章致谢（模板） 14 正文 感冒药中对乙酰氨基酚的解析电喷雾质谱快检分析 文1：感冒药中对乙酰氨基酚的解析电喷雾质谱快检分析 Abstract：　Based on the advantages of ambient mass spectrometry in the fast and direct detection on samples without any pre-treatment， an ambient mass spectrometric method was developed for the rapid and direct detection of drug the experiment， a home-made desorption electrospray ionization ( DESI) device was fabricated for the fast mass spectrometry ( MS) detection of commercial paracetamol tablets for the cold， achieving the molecule structural information of tablets without any the quantitative analysis of tablets by DESI-MS， the tablets of standard paracetamol were made starch used as the main matrix to avoid the effect of matrix on the optimized conditio， this method was applied in the quantitative detection of paracetamol in real showed that there was a good linear relatiohip for paracetamol in the range of mg/mm2 with a correlation coefficient ( r2) of limit of quantitation and limit of detection were ng/mm2 and ng/mm2， spiked recoveries for paracetamol were in the range of 102%-114%.The method was used for the direct detection of paracetamol in three commercial paracetamol with the data provided by the pharmaceutical manufacture， the relative standard deviatio ( D) of %-12% were present work confirmed that， with the advantages of drugs rapid detection， DESI-MS provided an efficient and effective tool for quality control of drugs。 Keyword：　desorption electrospray ionization mass spectrometry (DESI-MS) ; cold tablets; parac etamol; rapid detection of drugs; 抗感冒药种类繁多，但药物成分不尽相同，大多以对乙酰氨基酚、氯苯那敏、右美沙芬、伪麻黄碱、盐酸金刚烷胺等为主要成分，在解热镇痛、抗组胺作用、镇咳祛痰、收缩血管、抗病毒等方面发挥着重要作用。此外，还会添加其他药物，如咖啡因具有中枢兴奋作用，与对乙酰氨基酚合用，可以用于解热镇痛，起到联合治疗感冒的效果，但服用过多会产生恶心、肌肉震颤、甚至惊厥等症状。然而，市场上的感冒药，包括西药、中成药在内，品牌众多