胸腔镜微创手术对早期周围型肺癌患者术后炎症反应和免疫功能的影响（肿瘤学资料）.docVIP

胸腔镜微创手术对早期周围型肺癌患者术后炎症反应和免疫功能的影响（肿瘤学资料） 正文 胸腔镜微创手术对早期周围型肺癌患者术后炎症反应和免疫功能的影响（肿瘤学资料） 文1：胸腔镜微创手术对早期周围型肺癌患者术后炎症反应和免疫功能的影响 [Abstract]Objective To observe the effect of radical surgery thoracoscope on TNF alpha，IL-6，IL-10 and the level of T lymphocyte subsets of patients with early peripheral lung 78 patients with diagnosed early peripheral lung cancer in our hospital from August 2012 to December 2015 underwent surgery were included in the study and divided into open chest surgery group （n=40） and thoracoscopic group （n=38），patients in the open chest surgery group were treated with conventional thoracotomy，while patients in the thoracoscopic group underwent thoracoscopic resection of early peripheral lung of TNF alpha，IL-6，IL-10 in two groups were compared，and general situation and the differences in the levels of T lymphocyte subsets were The level of TNF alpha，IL-6，IL-10 of two groups both improved （）；fluctuation amplitude of CD3，CD4，CD8，CD4/CD8 were smaller in the thoracoscopic group （）.Conclusion Compared with conventional thoracotomy，thoracoscopic resection has the characteristics of obvious curative effect，less trauma and quick is worth popularizing。 [Key words]Thoracoscope；Early peripheral lung cancer；Radical resection；Inflammation facto；T lymphocyte subgroup level；Impact 周围型肺癌是发生于肺段以下支气管的癌症，发病与吸烟、遗传等因素相关，患者以男性为主[1]。临床症状个体差异较大，早期症状多不明显，早期由于瘤体小，易与其他疾病相混淆，不少患者于体检时才被发现。手术是重要的治疗手段，研究发现尽早的手术治疗能提高患者生存率[2]。传统开胸术存在创伤大，且易诱发感染等并发症，不利于患者病情的康复，使部分免疫力差的患者难以适应[3]。笔者采用胸腔镜早期周围型肺癌根治术治疗早期周围型肺癌效果显著，现报道如下。　1资料与方法 一般资料 将2012年8月～2015年12月于我院确诊的78例早期周围型肺癌并知情同意行手术治疗的患者纳入研究，依据手术方案进行分组，开胸手术组40例，胸腔镜组38例。开胸手术组中，男24例，女16例；年龄（±）岁；发病部位：左上肺叶11例，左下肺叶8例，右上肺叶8例，右下肺叶10例，右中肺叶3例；术后病理：大细胞癌2例，腺癌21例，鳞癌17例。胸腔镜组中，男性22例，女性16例；年龄（±）岁；发病部位：左上肺叶12例，左下肺叶7例，右上肺叶7例，右下肺叶9例，右中肺叶3例；术后病理：大细胞癌2例，腺癌20例，鳞癌16例。两组性别、年龄、发病部位、病理等一般资料比较，差异无统计学意义（P），具有可比性。诊断标准：分期及疾病诊断标准参照《临床肿瘤内科手册》[4]中本病的相关标准，可见刺激性干咳、咳痰、胸闷胸痛，肺部CT检查可提示占位，均行病理确诊。纳入标准：①符合诊断标准，术后病理分型均为Ⅰ型，要求手术治疗并知情同意者；②肝肾功能正常，且均经我院医学伦理委员会审核通过者；③KPS评分≥60者；④病理分期为Ⅰ期且肿瘤直径≤3 cm者。排除标准：①