左炔诺孕酮宫内缓释系统治疗子宫腺肌病的临床问题探讨（药学资料）.docVIP

左炔诺孕酮宫内缓释系统治疗子宫腺肌病的临床问题探讨（药学资料） 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：左炔诺孕酮宫内缓释系统治疗子宫腺肌病的临床问题探讨 1 1 资料与方法 3 2 结果 5 3 讨论 5 文2：左炔诺孕酮宫内缓释系统治疗子宫腺肌症的临床效果研究 6 1 资料与方法 7 2 结果 7 3 讨论 8 参考文摘引言： 9 原创性声明（模板） 10 文章致谢（模板） 10 正文 左炔诺孕酮宫内缓释系统治疗子宫腺肌病的临床问题探讨（药学资料） 文1：左炔诺孕酮宫内缓释系统治疗子宫腺肌病的临床问题探讨 Clinical effect observation of levonorgestrel releasing intrauterine system in the treatment of adenomyosis ZHAO Hong Department of Gynecology and Obstetrics，Jiangning Hospital Affiliated to Nanjing Medical Univeity，Nanjing 211100，China [Abstract] Objective To explore the clinical therapeutic effect of levonorgestrel releasing intrauterine system （LNG-IUS） in the treatment of adenomyosis. Methods Seventy-eight patients with adenomyosis admitted into our hospital from January 2010 to December 2012 were selected as research LNG-IUS was provided in all patients，and the clinical therapeutic effect was degree of dysmenorrhea，change of estradiol in blood，and metrual blood volume before and after treatment were statistical analyzed and compared. Results Twelve months after placing LNG-IUS，summarization of therapeutic effect indicated that pain greatly alleviated in 17 cases and disappeared in 54 that，there was no obvious effect in 5 cases and falling off in two 3，6，12 months，the metrual blood volume and compreheive score of pain had significant difference compared with before therapy （）. Conclusion LNG-IUS can obtain a remarkable clinical effect on treating adenomyosis and no significant inhibition on ovarian function occurred，which is worthy of further application and expaion in clinic. [Key words] Levonorgestrel；Releasing intrauterine system；Adenomyosis 作为一种常见的疾病，子宫腺肌病的发病患者多见于育龄妇女，其主要的临床症状是患者经量增多，经期显著延长，同时出现进行性痛经且会呈现逐步加重的趋势发展，因此使患者的生活质量受到了严重的影响[1]。目前对于该病的治疗主要以药物治疗为主，但是其存在治疗费用昂贵而且依从性差，同时长期的药物使用会产生很大的毒副作用，而且一旦停药，很容易出现疾病的复发。子宫的手术切除是对该疾病的一种根治方法，由于其方法对子宫的不可逆伤害，对于年轻患者或者是希望仍然保留生育功能的患者来讲，手术的方法也显得不实际[2]。本研究探讨左炔诺孕酮宫内缓释系统（LNG-IUS）治疗子宫腺肌病的临床效果。 1 资料与方法 一般资料 选择2010年1月～2012年