乳腺癌内乳淋巴结转移根治的相关性研究(药学资料).docVIP

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乳腺癌内乳淋巴结转移根治的相关性研究(药学资料).doc

乳腺癌内乳淋巴结转移根治的相关性研究(药学资料) 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1:乳腺癌内乳淋巴结转移根治的相关性研究 1 1 资料与方法 3 2 结果 4 3 讨论 4 文2:趋化因子受体CCR7在乳腺癌淋巴结转移中的作用 5 1材料和方法 6 参考文摘引言: 9 原创性声明(模板) 10 文章致谢(模板) 10 正文 乳腺癌内乳淋巴结转移根治的相关性研究(药学资料) 文1:乳腺癌内乳淋巴结转移根治的相关性研究 DOI:/-5547/.005 【Abstract】 Objective To investigate influence by corresponding modified radical mastectomy in sentinel lymph node biopsy on survival condition of breast cancer patients. Methods Among 158 patients with interior quadrant and areola breast cancer, 84 cases received no internal mammary sentinel lymph node biopsy and 74 cases received internal mammary sentinel lymph node biopsy. Change of pathological classification and influence on breast cancer metastasis were observed. Results Among 74 cases receiving internal mammary sentinel lymph node biopsy, 5 cases had changed pathological classification in internal mammary node of removed sentinel lymph node. Incidences of pulmonary metastasis and supraclavicular lymph node metastasis in non-internal mammary sentinel lymph node biopsy cases were % and %, which were higher than % and % in the cases receiving internal mammary sentinel lymph node biopsy (P). Conclusion Incidence of metastasis is obviously lower in patients receiving internal mammary node biopsy than those receiving no internal mammary node biopsy。 【Key words】 breast cancer; Sentinel lymph node biopsy; Internal mammary node; Modified radical mastectomy; Lymphatic metastasis 目前国内外通过对乳腺癌前哨淋巴结定位和活检技术预测腋下淋巴结的状况是可行的。但肿瘤位于内侧象限或中央区, 发生淋巴结转移首先是内乳淋巴结而不是腋淋巴结, 约有20%的乳腺癌向内乳淋巴结转移, 目前内乳淋巴结术中活检的报道较少, 相应的改良根治术研究甚少。使众多的位于内侧象限的乳腺癌患者失去了根治性手术的机会。因此应该在内侧象限乳腺癌患者中进行内乳淋巴结区的前哨淋巴结检查, 是国内外研究乳腺癌发展的一种趋势。为达到根治的目的, 本次研究设计了一种新的改良根治术式, 现报告如下。 1 资料与方法 1. 1 一般资料 本组病例为本院2009年3月~2013年5月住院的乳腺癌患者480例, 全部为女性。其中左侧233例, 右侧247例。年龄29~71岁, 平均年龄岁。肿瘤位置各异:位于乳腺外上象限212例, 外下象限110例, 内上象限60例, 内下象限64例, 乳晕周围34例。组织类型:浸润性导管癌445例, 髓样癌22例, 硬癌13例。选择位于内侧象限及乳晕周围乳癌患者数158例, 84例行常规的乳腺癌改良根治术(未行内乳前哨淋巴结活检), 74例行新式改良根治术(行内乳前哨淋巴结活检) 1. 2 对内侧象限乳腺癌前哨淋巴结的识别 患者在硬膜外或

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