肝脏病理课件ppt课件课件.ppt

Hepar Lobatum (cong. Syphilis): * 学习交流PPT HCC- The Global Perspective The Big Five Cancers * 学习交流PPT The Major Etiological Factors Chronic hepatitis - types B or C Cirrhosis/chronic liver disease of any type Aflatoxin exposure Males, increasing age * 学习交流PPT ?8% - High 2-7% - Intermediate 2% - Low Data from CDC Chronic HBV Infection - Geographic Distribution * 学习交流PPT Prospective Study of HCC Development in HBsAg Seropositive Male Chinese HCC DEVELOPMENT 19,223 (HBsAg -ve) 9 22,707 Mean follow-up = 8.9 years Male Chinese 3,454 (HBsAg +ve) 152 Relative risk = 98.4 (50.2-193) Beasley, 1982 * 学习交流PPT Beasley 1986 “The lifetime risk of developing Hepatocellular carcinoma In a Chinese male carrier Of the hepatitis B virus Is between 40 and 50%” * 学习交流PPT Chronic Viral Hepatitis HCC Okuda , 1999 * 学习交流PPT Anti-HCV Prevalence ?5% - High 1.1-5% - Intermediate 0.2-1% - Low 0.2-1% - Low Chronic HCV Infection - Geographic Distribution * 学习交流PPT Thank Your Attendance ! * 学习交流PPT 肝脏肿瘤 - Neoplasms of the Liver Hepatocellular Carcinoma and Cholangiocarcinoma * 学习交流PPT Pathology of Vascular Diseases of the Liver * 学习交流PPT References * 学习交流PPT Questions? * 学习交流PPT * * * * * * * * * * * * * * * * * * * * * * * * * * * This is a case of primary biliary cirrhosis, a rare autoimmune disease (mostly of middle-aged women) that is characterized by destruction of bile ductules within the triads of the liver. Antimitochondrial antibody can be detected in serum. Seen here in a portal tract is an intense chronic inflammatory infiltrate with loss of bile ductules. Micronodular cirrhosis ensues. * * * Antimitochondrial antibody can be