趋化因子及其受体.ppt

;; ; Massimo Gadina;Fig. 1. Model for the potential anti-inflammatory effects of IL-33.The dual effects of IL-33 activity are depicted. The precursor form of IL-33 is processed in the cytoplasm, possibly by the activity of a multiprotein caspase-1–containing complex known as an inflammasome. Once released from the cell, IL-33 binds its receptor complex at the cell surface. This complex, which contains ST2 and (by analogy to other IL-1 receptor family members) an as-yet-unidentified accessory receptor recruits the TIR domain–containing adaptor MyD88 to its intracellular domain through a homoty