支气管扩张剂作用的分子药理机制课件.pptx

支气管扩张剂作用的分子药理机制;Control of airway diameter;;Increased maximal airway narrowing in asthma ;;;;b2-Agonists;;b受体激动剂的母核;b2-agonists化学结构;人类b2肾上腺受体的分子结构;;b2激动剂激动b2受体(b2 AR)程序图;;;微动力学;;Johnson, Med Res Rev, 1995;Classes of b2-agonists ;福莫特罗 是 b2受体完全激动剂(full agonist) 沙美特罗 是 b2受体部分激动剂(partial agonist);Mechanism of action of b2-agonists ;AMPmethachaline/histamine protection = Mast cell stabilising effect;EFFECT OF INHALED b2-AGONWISTS ON PLASMA EXUDATION IN AIRWAYS;;减敏机制;;;;CNS;;; Receptor Location in Human Lung M1 Autonomic ganglia Submucosal glands Alveolar walls M2 Post-ganglionic parasympathetic nerves M3 Airway smooth muscle Submucosal glands Endothelial cells M4 Not detected M5 Not detected ;;Pre-ganglionicnerve;抗胆碱药物;抗胆碱药物;;;;茶碱;;Theophylline as an inhibitor of phosphodiesterases;;Multiple action of theophylline in asthma;联合治疗;急性炎症 ;Effect of wall area on airway resistance during Airway smooth muscle shortening;;;ASTHMA CONTROL;Corticosteroids;Cellular effects of glucocorticoids;Molecular Mechanism of Steroid Action;;激素与β激动剂的协同作用示意图;b2-AGONISTS ACTIVATE GLUCOCORTICOID RECEPTORS;;;;b2-Agonist;Thank you