浙江大学《遗传学》课件-chapter7 Phmarcogenetics.pptVIP

Malignant hyperthermia (MH。恶性高热) OMIM:145600. 1q13.1 Genetics of MH AD Incidence: rare, 1/5 000 –65 000 anesthetics, depending on drugs, populations, any ages, any races Male 2.4 x female The basic defect is the increase of intracellular Ca of skeletal muscle Spontaneous, animal models for MH were discovered in pigs and dogs MHS Gene Loci G-6-PD deficiency----favism Worldwide XR Xq28 Succinylcholine琥珀胆碱 OR suxamehonium sensitivity：butyrylcholinesterase丁酰胆碱酯酶, BChE (OMIM: 177400. 3q26.1-q26.2) Family Blames Soldiers Suicide on Anti-Malaria Drug. Washington Post, Oct. 12, 2008 CHICAGO --