痛风影像诊断.pptxVIP

CASE DISCUSSION;History ? Male,29Y ? Complaint:bilateral knee pain with intermittent fever fbr 4 years;? Laboratory examination Uric Acid (UA) : 478.3|imol/L| ? Treatment Allopurinol (ALLO);Final diagnosis ? Gouty Arthritis;Background ? Most classically in the first metatarsophalangeal joint (toe) ? A history of underlying renal disease or use of medications that cause hyperuricemia ? Gold standard : monosodium urate (MSU) crystals in the j oint fluid or tophus;Pathogenesis ? MSU crystals Lipids Protein Mucopolysaccharides ? The tophus eroding the underlying bone is pivotal in the developme