浅论Smad4和转化生长因子β受体Ⅱ在宫颈腺癌中的表达及意义（临床医学论文资料）.doc

浅论Smad4和转化生长因子β受体Ⅱ在宫颈腺癌中的表达及意义（临床医学论文资料） 文档信息 ： 文档作为关于“医学心理学”中“烧伤科”的参考范文，为解决如何写好实用应用文、正确编写文案格式、内容素材摘取等相关工作提供支持。正文8968字，doc格式，可编辑。质优实惠，欢迎下载！ 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：浅论Smad4和转化生长因子β受体Ⅱ在宫颈腺癌中的表达及意义 2 1 对象与方法 3 2 结 果 4 3 讨 论 5 文2：Smad4和转化生长因子β受体Ⅱ在宫颈腺癌中的表达及意义临床医学论文 6 1 对象与方法 8 2 结 果 9 3 讨 论 10 参考文摘引言： 11 原创性声明（模板） 13 文章致谢（模板） 13 正文 浅论Smad4和转化生长因子β受体Ⅱ在宫颈腺癌中的表达及意义（临床医学论文资料） 文1：浅论Smad4和转化生长因子β受体Ⅱ在宫颈腺癌中的表达及意义 [Abstract] Objective: To study the correlation of the expression of Smad4 and TGFβ receptor Ⅱ( TβRⅡ) with clinical pathology in cervical adenocarcinoma， and to explore its possibility as a marker to decide the prognosis of cervical ： To detect the expression of Smad4 and TβRⅡin 36 cases of cervical adenocarcinoma and 20 cases of normal cervical glandular epithelium tissue and to investigate the relation between the expression of Smad4 with TβRⅡand clinical pathology. Results： The expression of Smad4 and TβRⅡin cervical adenocarcinoma is significantly lower than normal cervical glandular epithelium tissue().The expression of Smad4 and TβRⅡin cervical adenocarcinoma with poor differentiated was significantly lower than that of moderate or well differentiated().The expression of Smad4 and TβRⅡis significantly lower in cervical adenocarcinoma with metastatic lymph nodes than in the tissue with no metastatic lymph nodes().The expression of Smad4 and TβRⅡ was significantly related with clinical stage(). Conclusion： The deleted expression of Smad4 and TβRⅡ was associated with development， advanced， differentiated and metastasis in cervical and TβRⅡmay be a marker for differentiated and metastasis of cervical detect Smad4 and TβRⅡmay be a useful tumor marker to decide the prognosis of cervical adenocarcinoma。 [Key words] Smad4; TGFβ receptor Ⅱ ; cervical adenocarcinoma; prognosis 宫颈腺癌近年来在宫颈癌中所占的比例明显增高[1]，宫颈腺癌较宫颈鳞癌更易于发生转移，预后差。其主要死亡原因是术后复发和转移。临床尚无可靠方法做到早期预测。因此，对宫颈腺癌复发和转移等预后指标的生物学标志物的研究有非常重要的意义。转化生长因子βⅡ型受体(TβRⅡ)可直接结合