pathogeniccocci病原性球菌学习.pptxVIP

1. Pathogenic cocci Concept of pathogenic bacteria 13min Staphylococcus (Esp., S. aureus) 56min Streptococcus (Esp., S. pyogenes) 38min Enterococcus species and VRE 5min Neisseria meningitides Neisseria gonorrhoeae 13min 2. Other bacteria Pseudomonas aeruginosa 10min ;Up to every pathogen, the following will be talked:;Pustule (脓疱) by S. aureus;Pustule (脓疱) by S. aureus;Sore throat (咽喉炎) by S. pyogenes;Untreated erysipelas (丹毒) by S. pyogenes with skin sloughing and necrosis ;Necrotizing Fasciitis (坏死性筋膜炎) by flesh-eating bacteria (S. pyogenes, anaerobic bacteria, etc.), and insects (bee, etc.) stinging;Chest x-ray Film 1 just a few hours of rigors and productive cough ;Meningococcal septicemia (脑膜炎球菌性败血症) by N. meningitidis, widespread ecchymoses ;Gonococcal conjunctivitis (淋菌性结膜炎) by N. gonorrhoeae ;Causative agents of above clinical diseases?; What is Pathogenic cocci ? also called — Pyogenic cocci (化脓性球菌); Important cocci;Staphylococcus aureus; Shape, Stain Culture spherical, elliptical, irregular grape-like cluster Gram+ (G+) Grow well on basic medium;第16页/共95页;第17页/共95页; Antigenic structure Staphylococcal protein A (SPA) One kind of surface protein in cell wall Single chain peptide Actions — Binds (bacterium) to host’s IgG1, IgG2 IgG4 coagglutination test Competes w/ Fc receptors of phagocytes resists phagocytosis ;Coagglutination test with inert particles (e.g., heat-killed S. aureus or latex beads) ;; Capsule Teichoic acid (polysaccharide) polysaccharide A— S. aureus polysaccharide B— S. epidermidis;Important Properties of 3 Main Species of Staphylococci;Pathogenicity immunity;Coagulase, Fibrinolysin, Heat stable nuclease, Hyaluronidase, Lipase;Coagulase; Virulence Protection actions Infection localized; classified into ?-, ?-, ?-, ?-toxin ?-toxin— makes pores in cell membranes;; including type A type B causes staphylococcal s