《病理学》英文课件：02 Hemodynamic Disorders.pptVIP

Occlusive thrombus thrombosis Vegetation * . tumor thrombus bacterial thrombus thrombosis * . thrombosis Difference between thrombus and postmortem clot Thrombus Postmortem clots 干 dry wet and gelatinous “chicken fat” supernatant 糙 rough surface smooth surface 硬 hard soft 脆 fragile gelatinous 层 Lines of Zahn homogenous 紧 firmly attached no attachment 裂 slit due to contraction, fragmentation, generate embolus no slit * . thrombosis Fate Obstruction Dissolution Embolization Organization Recanalization Calcification * . thrombosis Arterial thrombi originate from injury sites Venous thrombi (phlebothrombi) originate from the sites of stasis both extend to the heart * . thrombosis Clinical correlations Venous thrombosis (phlebothrombosis) varicosities, embolism (sometimes fatal), DVT, trauma, surgery, post partum cancer associated thrombosis Cardiac and arterial thrombosis mural thrombus (MI, AS) myocardiac infarction, rheumatic heart disease Embolize peripherally, brain, kidney, spleen, etc * . thrombosis DIC (Disseminated Intravascular Coagulation) ? Usually happens in many severe disorders severe bacterial or viral infection, allergic disease, anoxia, trauma, shock, malignancy ,etc. ? Coagulation System is Activated Microthrombi are formed in Cap. of many organs Platelets + Fibrin ( lung ,brain ,kidney, liver, GI tract, adrenal gland, etc.) ? Consumption of coagulation substance and activation of fibrinolytic system hemorrhage diathesis, multiorgan dysfunction consumption coagulopathy / defibrination syndrome 消耗性凝血病/ 去纤维蛋白综合征 * . Embolism （栓塞） Occlusion of cardiovascular system by some insoluble mass. 血液循环中出现的不溶于血液的异常物质(embolus)，随血流运行阻塞血管腔的现象称为栓塞 The mass --Embolus （栓子）: solid, liquid, gaseous mass Thromboembolism 99% Fat, air, amniotic fluid, tumor fragments, bits of bone marrow, etc. * . Embolism Route of emboli Arterial emboli —— systemic e