细胞凋亡线粒体途径的调控精.pptxVIP

会计学;Execution of mitochondrial apoptosis signals;Release of cytochrome c;第3页/共49页;Release of Smac;Release of apoptosis-inducing Factor(AIF);Release of endonuclease G;Features of mitochondria-initiated apoptosis;第8页/共49页; the pathway is able to feed-forward and amplified the apoptotic signal. Even when caspase-dependent and caspase-independent pathway cannot function properly, mitochondrial dysfunction may lead to cell death.;Disruption of electron transport and energy metabolism. Release of caspase-activating proteins. Alteration of cellular reduction-oxidation potential ;Regulation of mittoc