慢性阻塞性肺疾病患者sTREM1的测定及其意义（临床医学范文）.docVIP

慢性阻塞性肺疾病患者sTREM1的测定及其意义（临床医学范文） 目录 TOC \o 1-9 \h \z \u 目录 1 正文 2 文1：慢性阻塞性肺疾病患者sTREM1的测定及其意义 2 1 材料和方法 3 1.1 标本采集对象 3 1.2 确定入选标准 3 1.3 剔除标准 4 1.4 外周血和痰液标本收集及处理 4 1.5 测定外周血和痰液中sTREM1的浓度 4 1.6 肺功能测定 4 1.7 统计学处理 5 文2：慢性阻塞性肺疾病患者sTREM1的测定及其意义 5 1 材料和方法 6 1.1 标本采集对象 6 1.2 确定入选标准 7 1.3 剔除标准 7 1.4 外周血和痰液标本收集及处理 7 1.5 测定外周血和痰液中sTREM1的浓度 7 1.6 肺功能测定 8 1.7 统计学处理 8 2 结 果 8 2.1 外周血白细胞计数（109/L） 8 2.2 痰液白细胞计数 （109/L） 8 2.3 痰液及血清sTREM1浓度 9 2.5 以肺功能为因变量的多元线性回归分析 9 3 讨 论 9 参考文摘引言： 10 原创性声明（模板） 12 文章致谢（模板） 12 正文 慢性阻塞性肺疾病患者sTREM1的测定及其意义（临床医学范文） 文1：慢性阻塞性肺疾病患者sTREM1的测定及其意义 ABSTRACT: Objective To investigate the contents of sTREM1 in peripheral blood and sputum from patients with COPD, and to analyze the correlation between sTREM1 and severity of COPD. Methods The levels of sTREM1 in peripheral blood and sputum were determined by ELISA in 12 acute exacerbation of COPD subjects, 2 weeks after treatment, stable COPD subjects, and 12 healthy individuals. The total white cell counts, pulmonary function tests were performed at the same time. The relatiohip between the content of sTREM1 in sputum from patients with acute exacerbation of COPD and FEV1 was analyzed. Results The content of sTREM1 in sputum from acute exacerbation of COPD group and 2 weeks after treatment was significantly higher than that in stable group, but in peripheral blood, they was no significant diference as compared with control group. The level of sTREM1 in sputum from acute exacerbation of COPD was significantly negative correlated with FEV1%. Conclusion The airway inflammation can be reflected by the content of sTREM1 in sputum from patients with acute exacerbation of COPD, and the level of sTREM1 may be a prognosis index of FEV1% KEY WORDS: COPD;Airway inflammation;sTREM1;WBC;Pulmonary function 慢性阻塞性肺疾病（COPD）是以气道、肺实质和肺血管的慢性炎症为特征的病变[1]。研究表明[2]，感染为COPD急性加重的主要诱发因素，其中细菌感染在发病中起重要作用，而频繁的发作是肺功能下降的重要原因。Boucho