BC-1215-DataSheet-生命科学试剂-MedChemExpress.pdf免费

Hotline: 400-820-3792 Inhibitors • Agonists • Screening Libraries www.MedChemE BC-1215 Cat. No.: HY-117937 CAS No.: 1507370-20-8 分⼦式: C₂₆H₂₆N₄ 分⼦量: 394.51 作⽤靶点: Ligand for E3 Ligase 作⽤通路: PROTAC 储存⽅式: Please store the product under the recommended conditions in the COA. BIOLOGICAL ACTIVITY ⽣物活性 BC-1215 是 F-box protein 3 (FBXO3) 的抑制剂，IL-1 β 释放时，IC50 值为 0.9 μg/mL。 BC-1215 降低 Fbxo3- Fbx12 相互作⽤并且阻⽌ SCFFbxo3 催化的 Fbxl2 泛素化。 BC-1215 通过稳定 TRAF1-TRAF6 来抑制 Fbxo3- TRAF 激活途径。BC-1215 与 ApaG 相互作⽤，抑制来⾃⼈ PBMC ⼴谱 TH1 细胞因⼦的分泌。 REFERENCES [1]. Chen BB, et al. A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulateinflammation. Nat Immunol. 2013 May;14(5):470-9. McePdfHeight Caution: Product has not been fully validated for medical applications. For research use only. Tel: 400-820-3792; 021 Fax: 021 E-mail: tech@MedChemE 1/1 Master of Small Molecules — 您⾝边的抑制剂⼤师