cGAMP-diammonium-Cyclic-GMP-AMP-diammonium-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE cGAMP diammonium Cat. No.: HY-110385A Synonyms: Cyclic GMP-AMP diammonium; 3,3-cGAMP diammonium 分⼦式: C₂₀H₃₀N₁₂O₁₃P₂ 分⼦量: 708.47 作⽤靶点: STING; Endogenous Metabolite 作⽤通路: Immunology/Inflammation; Metabolic Enzyme/Protease 储存⽅式: Please store the product under the recommended conditions in the Certificate of Analysis. BIOLOGICAL ACTIVITY ⽣物活性 cGAMP (Cyclic GMP-AMPP) diammonium 作为内源性第⼆信使发挥作⽤，并触发⼲扰素的产⽣以响应胞浆 DNA。cGAMP diammonium 激活⼲扰素基因刺激因⼦ (STING)，激活导致产⽣ I 型⼲扰素和其他免疫介质的信 号级联。 IC50 Target Human Endogenous Metabolite 体外研究 cGAMP diammonium promotes the antigen-specific proliferation capacity of spleen cells in mice [2]. cGAMP diammonium directly activates murine and human dendritic cells in vitro [2]. On stimulation with cGAMP diammonium, fibroblasts from the patients showed increased transcription of IFNB1 but not of the genes encoding interleukin-1 (IL1), interleukin-6 (IL6), or tumor necrosis factor (TNF) [3]. cGAMP diammonium activates the endoplasmic reticulum (ER)-resident receptor STING, thereby inducing an antiviral state and the secretion of type I IFNs [4]. 体内研究 cGAMP (5 µg; nostril mucosal adjuvant) diammonium promotes the antigen-specific cytokine production by