12-HETE-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE 12-HETE Cat. No.: HY-113439 CAS No.: 71030-37-0 分⼦式: C₂₀H₃₂O₃ 分⼦量: 320.47 作⽤靶点: Apoptosis 作⽤通路: Apoptosis 储存⽅式: Please store the product under the recommended conditions in the Certificate of Analysis. BIOLOGICAL ACTIVITY ⽣物活性 12-HETE 是花⽣四烯酸在 12-LOX 催化下的主要代谢产物，抑制细胞凋亡。12-HETE 通过整合素连接激酶 (ILK) 通路促进 NF- κB 的活化和核转位 [1]。12-HETE 具有抗⾎栓形成和促⾎栓形成作⽤ [2]。12-HETE 还是⼀种神 经调节剂 [3]。 体外研究 12-HETE participates in the inhibition of cell apoptosis by activating the ILK/NF-κB pathway, implying an important underlying mechanism that promotes the survival of ovarian cancer cells. 12-HETE facilitates cell survival by activating the integrin-linked kinase/NF-κB pathway in ovarian cancer. 12-HETE protects against cell apoptosis in ovarian cancer cells in a concentration-dependent manner. 12-HETE (1 µM) significantly decreases the activation of caspase-3 induced by serum deprivation (SD).12-HETE represses the increased activity of caspase-3 induced by SD in a concentration-dependent manner, with an IC50 value of 1.13 µM [1]. 12-HETE (1 µM) facilitates the activation and nuclear translocation of NF-κB via ILK in ovarian cancer cells