AAA-10-formic-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE AAA-10 formic Cat. No.: HY-145147A 分⼦式: C₂₆H₄₃FO₇S 分⼦量: 518.68 作⽤靶点: Bacterial 作⽤通路: Anti-infection 储存⽅式: Please store the product under the recommended conditions in the Certificate of Analysis. BIOLOGICAL ACTIVITY ⽣物活性 AAA-10 formic 是⼀种具有⼝服活性的肠道细菌胆盐⽔解酶 (BSH) 抑制剂，对B. theta rBSH 和 B. longum rBSH 的 IC50 值分别为 10 nM, 80 nM [1]。 IC50 Target IC50: 10 nM (B. theta rBSH), 80 nM (B. longum rBSH) [1] 体外研究 AAA-10 (100 μM; 24 h) formic inhibits BSH activity in bacterial cultures, with IC50s of 74 nM, 901 nM for Gram-negative and Gram-positive bacteria, respectively [1]. AAA-10 (20 μM; 2 h) formic significantly inhibits deconjugation of glycochenodeoxycholic acid-d4 or taurocholic acid-d4 substrates of human feces [1]. 体内研究 AAA-10 (30 mg/kg; orally gavage daily for 5 days) formic decreases the abundances of deoxycholic acid (DCA) and lithocholic acid (LCA) in mice feces starting in day 2-5 [1]. AAA-10 (30 mg/kg) formic displays high colonic exposure and low gut permeability [1]. Animal Model: 10-11 weeks old male C57Bl/6J mice [1] Dosage: 30 mg/kg Administration: Orally gavaged o