3-Phenylpropyl-isothiocyanate-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE 3-Phenylpropyl isothiocyanate Cat. No.: HY-115771 CAS No.: 2627-27-2 分⼦式: C₁₀H₁₁NS 分⼦量: 177.27 作⽤靶点: Others 作⽤通路: Others 储存⽅式: Please store the product under the recommended conditions in the Certificate of Analysis. BIOLOGICAL ACTIVITY ⽣物活性 3-Phenylpropyl isothiocyanate 对N-亚硝基甲基苄胺 (NMBA) 肿瘤的发⽣有较强的抑制作⽤。3-Phenylpropyl isothiocyanate 具有化学预防作⽤。 体内研究 3-Phenylpropyl isothiocyanate (5, 1, or 0.2 µmol; gavage; A/J mice; daily for 4 consecutive days prior to administration of 10 µmol of NNK by i.p. injection) effectively inhibited NNK-induced lung tumors. REFERENCES [1]. Morse MA, et al. Structure-activity relationships for inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone lung tumorigenesis by arylalkyl isothiocyanates in A/J mice. Cancer Res. 1991;51(7):1846-1850. [2]. Nishikawa A, et al. Chemopreventive effects of 3-phenylpropyl isothiocyanate on hamster lung tumorigenesis initiated with N- nitrosobis(2-oxopropyl)amine. Jpn J Cancer Res. 1996;87(2):122-126. McePdfHeight Caution: Product has not been fully validated for