3-Hydroxykynurenine-3-Hydroxy-DL-kynurenine-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE 3-Hydroxykynurenine Cat. No.: HY-113294 CAS No.: 484-78-6 Synonyms: 3-Hydroxy-DL-kynurenine 分⼦式: C₁₀H₁₂N₂O₄ 分⼦量: 224.21 作⽤靶点: Endogenous Metabolite; Apoptosis 作⽤通路: Metabolic Enzyme/Protease; Apoptosis 储存⽅式: Please store the product under the recommended conditions in the Certificate of Analysis. BIOLOGICAL ACTIVITY ⽣物活性 3-Hydroxykynurenine 是⼀种⾊氨酸代谢物，是潜在的内源性神经毒素，在⼏种神经退⾏性疾病中表达⽔平都 有升⾼的现象。3-Hydroxykynurenine 诱导神经细胞凋亡 (apoptosis) [1]。 IC50 Target Human Endogenous Metabolite 体外研究 3-Hydroxykynurenine-induced neuronal cell death shows several features of apoptosis [1]. 3-Hydroxykynurenine is a metabolic intermediate of the kynurenine pathway, the major metabolic pathway of tryptophan (Trp) [1]. 3-Hydroxykynurenine acts as an endogenous neurotoxin in the brain under pathological conditions [1]. 3-Hydroxykynurenine (20-100 μM) significantly inhibits CD4+ T-cell proliferation in a dose-dependent manner with IC50 of approximately 70 μM [2]. 3-Hydroxykynurenine (20-100 μM) induces significant CD4+ T-cell-mediated cell death in a dose-dependent manner [2]. Cell Proliferation Assay [2]