D-L-erythro-PDMP-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE D,L-erythro-PDMP Cat. No.: HY-116392G CAS No.: 109760-77-2 分⼦式: C₂₃H₃₈N₂O₃ 分⼦量: 390.56 作⽤靶点: Others 作⽤通路: Others 储存⽅式: Please store the product under the recommended conditions in the Certificate of Analysis. BIOLOGICAL ACTIVITY ⽣物活性 D,L-erythro-PDMP 是 PDMP 的⾚型异构体。D,L-erythro-PDMP 诱导体外兔⽪肤成纤维细胞的⽣长抑制。 PDMP 是⼀种 UDP 葡萄糖神经酰胺葡萄糖基转移酶抑制剂 [1] [2]。 体外研究 D,L-erythro-PDMP (0, 12, 25, 50 μM; 0, 4, 7, 10 days) shows an inhibitory effect on cell growth of rabbit skin fibroblasts [1]. D,L-erythro PDMP (50 μM; 3 days) has cytotoxic of rabbit skin fibroblasts on cell morphology [1]. D,L-erythro-PDMP (40 μM; 24 h; MDCK cells) induces a marked increase in glucosyltransferase specific activity: 14.6 nmol/h per mg protein [2]. D,L-erythro-PDMP (40 μM; 6 h) protects the cells against loss of synthase in cells exposed to cycloheximide [2]. Cell Proliferation Assay [1] Cell Line: Rabbit skin fibroblast Concentration: 0, 12, 25, 50 μM Incubation Time: 0, 4, 7, 10 days Result: Showed an inhibitory effect on cell growth.