Ebselen-oxide-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE Ebselen oxide Cat. No.: HY-114548 CAS No.: 104473-83-8 分⼦式: C₁₃H₉NO₂S 分⼦量: 290.18 作⽤靶点: Guanylate Cyclase 作⽤通路: GPCR/G Protein 储存⽅式: Please store the product under the recommended conditions in the Certificate of Analysis. BIOLOGICAL ACTIVITY ⽣物活性 Ebselen oxide，Ebselen的 硒酮类似物，通过共价修饰⼆鸟苷酸环化酶 (DGC) 以抑制 c-di-GMP 受体相互作⽤ 并降低 DGC 活性。Ebselen oxide 还抑制 Pseudomonas aeruginosa 产⽣藻酸盐 (alginate)，IC50 为 14 μ M。Ebselen oxide 抑制 HDAC1、HDAC3、HDAC4、HDAC5、HDAC6、HDAC7、HDAC8 和 HDAC9 (IC50 范 围为 0.2 ⾄ 4.7 μM)。 体外研究 Ebselen oxide, is a covalent inhibitor of c-di-GMP allosteric binding to I-site containing proteins, diguanylate cyclase (DGC) activity [1]. Ebselen oxide inhibits diguanylate cyclase from synthesizing c-di-GMP. Ebselen oxide exhibits increased potency on HDAC8 (IC50=0.2 μM) in comparison with Ebselen [3]. REFERENCES [1]. Lieberman OJ, et al. High-throughput screening using the differential radial capillary action of ligand assay identifies e