HNMPA-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE HNMPA Cat. No.: HY-101962 CAS No.: 132541-52-7 分⼦式: C₁₁H₁₁O₄P 分⼦量: 238.18 作⽤靶点: Insulin Receptor 作⽤通路: Protein Tyrosine Kinase/RTK 储存⽅式: Please store the product under the recommended conditions in the Certificate of Analysis. BIOLOGICAL ACTIVITY ⽣物活性 HNMPA 是⼀种膜不可渗透的胰岛素受体酪氨酸激酶 (insulin receptor tyrosine kinase) 抑制剂。HNMPA 抑制 ⼈胰岛素受体的丝氨酸和酪氨酸⾃磷酸化。HNMPA 对蛋⽩激酶 C 或环 AMP 依赖性蛋⽩激酶活性没有影响。 体外研究 HNMPA inhibits the phosphorylation of a synthetic peptide substrate composed of insulin receptor residues 1290-1319 on serines-1305/1306 by partially purified insulin receptors [1]. HNMPA blocks GABA-dependent insulin inhibition, and reduces neuronal firing after GABA application [2]. REFERENCES [1]. K Baltensperger, et al. Catalysis of serine and tyrosine autophosphorylation by the human insulin receptor. Proc Natl Acad Sci U S A. 1992 Sep 1;89(17):7885-9. [2]. Peter Kovacs, et al. In vivo electrophysiological effects of insulin in the rat brain. Neuropeptides. 2009 Aug;43(4):283-93. McePdfHeight Caution: Produ