Decylubiquinone-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE Decylubiquinone Cat. No.: HY-121134 CAS No.: 55486-00-5 分⼦式: C₁₉H₃₀O₄ 分⼦量: 322.44 作⽤靶点: Reactive Oxygen Species 作⽤通路: Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB 储存⽅式: Please store the product under the recommended conditions in the Certificate of Analysis. BIOLOGICAL ACTIVITY ⽣物活性 Decylubiquinone 是泛醌 (辅酶 Q10) 的类似物。Decylubiquinone 阻⽌活性氧 (ROS) 的产⽣以响应⾕胱⽢肽消 耗并抑制线粒体通透性转变的激活 [1]。 体外研究 Decylubiquinone (dUb; 10 μm for 6 hours) exerts its effects on ROS by either inhibition of ROS production by cytochrome bc1 or that it scavenged ROS produced [1]. Decylubiquinone inhibits both the dichlorofluorescein (DCF) fluorescence increase resulting from H2O2 treatment and the DCF fluorescence increase resulting after glutathione (GSH) depletion using diethylmaleate mitochondrially generated ROS) [1]. Cell Viability Assay [1] Cell Line: HL60 cells transfected with bcl-2 (bcl-2) (HL60 B cells)