Anabaseine-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE Anabaseine Cat. No.: HY-115766 CAS No.: 3471-05-4 分⼦式: C₁₀H₁₂N₂ 分⼦量: 160.22 作⽤靶点: nAChR 作⽤通路: Membrane Transporter/Ion Channel; Neuronal Signaling 储存⽅式: Please store the product under the recommended conditions in the Certificate of Analysis. BIOLOGICAL ACTIVITY ⽣物活性 Anabaseine 是⼀种⾮选择性烟碱受体激动剂。Anabaseine 刺激所有的 AChRs，优先刺激⾻骼肌和⼤脑的 α7 亚型 [1] [2]。Anabaseine 也是 α4β2 nAChRs 弱的部分激动剂 [3]。 IC50 Target AChRs [1] 体外研究 Anabaseine is a full agonist at α7 AChR in the central nervous system (CNS) and a full agonist at α1β1ɛδ and α1β1γδ (Torpedo) in the peripheral nervous system [1]. Anabaseine acts as neuromuscular agonist on the frog rectus abdominis muscle (EC50: 0.25-0.74 μM) [1]. 体内研究 Anabaseine (3.6 μmol/kg; subcutaneous injection) elevates ACh levels [1]. REFERENCES [1]. Kem W, et al. The Nemertine Toxin Anabaseine and Its Derivative DMXBA (GTS-21): Chemical and Pharmacological Properties. Mar Drugs. 2006;4(3):255-273. [2]. Summers KL et al. Nicotinic agonist modulat