Dimethyl-F-OICR-9429-COOH-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE Dimethyl-F-OICR-9429-COOH Cat. No.: HY-141799 CAS No.: 2407458-49-3 分⼦式: C₂₇H₂₆F₄N₄O₄ 分⼦量: 546.51 作⽤靶点: Ligands for Target Protein for PROTAC 作⽤通路: PROTAC 储存⽅式: Please store the product under the recommended conditions in the Certificate of Analysis. BIOLOGICAL ACTIVITY ⽣物活性 Dimethyl-F-OICR-9429-COOH 是⼀种靶蛋⽩ WD40 重复域蛋⽩ 5 (WDR5) 的配体，可⽤于 PROTAC 的合成。 详细信息请参考专利⽂献 WO2019246570A1 中的中间体 19。 IC50 Target Ligand for Target Protein for PROTAC [1] 体外研究 PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1]. REFERENCES [1]. Jin J, et, al. Wd40 repeat domain protein 5 (wdr5) degradation/disruption compounds and methods of use. WO2019246570A1. McePdfHeight Caution: Product has not been fully validated for medical applications. For research use only. T