DL-AP7-2-APH-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE DL-AP7 Cat. No.: HY-100782 CAS No.: 85797-13-3 Synonyms: 2-APH; 2-Amino-7-phosphonoheptanoic acid 分⼦式: C₇H₁₆NO₅P 分⼦量: 225.18 作⽤靶点: iGluR 作⽤通路: Membrane Transporter/Ion Channel; Neuronal Signaling 储存⽅式: Please store the product under the recommended conditions in the Certificate of Analysis. BIOLOGICAL ACTIVITY ⽣物活性 DL-AP7 是⼀种竞争性 NMDA 拮抗剂和抗惊厥剂。DL-AP7 阻断 NMDA 诱导的惊厥并损害⼩⿏被动回避任务的 学习能⼒。 体内研究 DL-AP7 (ICV) blocks the NMDA-induced convulsions (ED50=0.22 nmol/mouse) and impairs learning performance in a passive avoidance task in mice [1]. REFERENCES [1]. Chiamulera C, et al. Effect of NMDA- and strychnine-insensitive glycine site antagonists on NMDA-mediated convulsions and learning. Psychopharmacology (Berl). 1990;102(4):551-552. McePdfHeight Caution: Product has not been fully validated for medical applications. For research use only. Tel: 400-820-3792; 021 Fax: 021 E-mail: tech@MedChemE 1/1