NOS-IN-2-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE NOS-IN-2 Cat. No.: HY-115916 分⼦式: C₁₈H₂₀F₃N₃O₂ 分⼦量: 367.37 作⽤靶点: NO Synthase 作⽤通路: Immunology/Inflammation 储存⽅式: Please store the product under the recommended conditions in the Certificate of Analysis. BIOLOGICAL ACTIVITY ⽣物活性 NOS-IN-2 (Compound 4i) 是⼀个强效的、选择性的由 imidamide 衍⽣的 NOS 抑制剂，对 iNOS 的 IC50 值为 20 µM。NOS-IN-2 不抑制 eNOS，⼏乎没有毒性，可⽤于研究炎症性疾病 [1]。 IC50 Target IC50: 20 µM (iNOS), 1000 µM (nNOS) [1] 体外研究 NOS-IN-2 (Compound 4i) shows high iNOS selectivity without eNOS inhibition activity [1]. NOS-IN-2 (0-100 µM, 30 min) has little toxicity [1]. Cell Viability Assay [1] Cell Line: HUVECs Concentration: 10, 20, 50, 100, 500 µM Incubation Time: 30 min Result: Had little toxicity, only at the concentration above 100 µM, the cell viability was significantly (approximately 20%) reduced. 体内研究 NOS-IN-2 (Compound 4i) is predicted to show oral bioavailability [1]. REFERENCES [1]. Fabio Arias, et al. Synthesis, bioevaluation and docking studies of new imidamide derivatives as nitric oxide synthase inhibitors. Bioorg Med Chem. 2021 Aug 15;44:116294. 1/2