EGFR-IN-45-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE EGFR-IN-45 Cat. No.: HY-145867 分⼦式: C₂₈H₂₃N₇O 分⼦量: 473.53 作⽤靶点: Topoisomerase; EGFR; CDK; Apoptosis 作⽤通路: Cell Cycle/DNA Damage; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Apoptosis 储存⽅式: Please store the product under the recommended conditions in the Certificate of Analysis. BIOLOGICAL ACTIVITY ⽣物活性 EGFR-IN-45 是⼀种有效的表⽪⽣长因⼦受体 (EGFR) 泛抑制剂，对 EGFR 和 CDK2 的 IC50 分别为 0.4 µM 和 1.6 µM。EGFR-IN-45 也抑制拓扑异构酶 Topo I 和 Topo II。EGFR-IN-45 能将癌细胞抑制在 G1 前期，诱导细胞凋 亡 (apoptosis) [1]。 IC50 Target CDK2 EGFR 1.6 μM (IC50) 0.4 μM (IC50) 体外研究 EGFR-IN-45 (compound 30b) (0-10 μM; 48 hours) exhibits the high anticancer activity against Panc-1, MCF- 7, HT-29 and A-549 [1]. EGFR-IN-45 (20 and 100 μM; hours) can inhibit Topo I and Topo II in a dose-dependent manner [1]. EGFR-IN-45 (0-8 μM; 24 hours) has a high percentage of cell accumulation in the pre-G1 phase in MCF-7 [1]. EGFR-IN-45 (0-8 μM; 24 hours) induces high amounts of apoptosis, with a necrosis percent of 2.99 [1]. Cell Proliferation Assay