Discovering functional gene epression patterns in the metabolic network of Escherichia coli分析和总结最新分析和总结.docxVIP

Discovering functional gene expression patterns in the metabolic network of Escherichia coliwith wavelets transforms Rainer K?nig, #1,2 Gunnar Schramm,#2 Marcus Oswald,3 Hanna Seitz,3 Sebastian Sager,4 Marc Zapatka,2 Gerhard Reinelt,3 and Roland Eils1,2 1Department of Bioinformatics and Functional Genomics, Institute for Pharmacy and Molecular Biotechnology, University of Heidelberg, 69120 Heidelberg, Germany 2Theoretical Bioinformatics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany 3Institute of Computer Science, University of Heidelberg, 69120 Heidelberg, Germany 4Interdisciplinary Center for Scientific Computing, University of Heidelberg, 69120 Heidelberg, Germany Corresponding author. #Contributed equally. Rainer K?nig: r.koenig@dkfz.de ; Gunnar Schramm: g.schramm@dkfz.de ; Marcus Oswald: Marcus.Oswald@Informatik.Uni-Heidelberg.de Hanna.Seitz@Informatik.Uni-Heidelberg.de ; Hanna Seitz: m.zapatka@dkfz.deEils: m.zapatka@dkfz.de Eils: r.eils@dkfz.de Sebastian.Sager@iwr.uni-heidelberg.de ; Marc Zapatka: ; Gerhard Reinelt: Gerhard.Reinelt@Informatik.Uni-Heidelberg.de ; Roland Received August 25, 2005; Accepted March 8, 2006. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( /licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This article has been cited by other articles in PMC. Top Abstract Background Results and discussion Conclusion Methods List of abbreviations Authors contributions Supplementary Material References Abstract Background Microarray technology produces gene expression data on a genomic scale for an endless variety of organisms and conditions. However, this vast amount of information needs to be extracted in a reasonable way and funneled into manageable and functionally meaningful patterns. Genes may be reasonably combined using knowledge about their interaction beha