恶性肿瘤的分子生物学.pptVIP

Genetic Control of Neoplastic Initiation and Promotion Gatekeeper genes Caretaker genes 现在是31页\一共有52页\编辑于星期四 Examples of tumour suppressor genes include RB1 - retinoblastoma susceptibility gene WT1 - Wilms tumour gene NF1 - neurofibromatosis type 1 gene NF2 - neurofibromatosis type 2 gene DCC - involved in colorectal cancer BRCA1, BRCA2 - involved in breast cancer 现在是32页\一共有52页\编辑于星期四 Today we will look at these tumour suppressor genes: Rb (视网膜母细胞瘤) p53 APC (腺瘤样结肠息肉) 现在是33页\一共有52页\编辑于星期四 现在是34页\一共有52页\编辑于星期四 Knudson’s “Two-Hit” Model for Retinoblastoma Normal 2 intact copies Pred