Coronarin-A-DataSheet-生命科学试剂-MCE.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE Coronarin A Cat. No.: HY-N3628 CAS No.: 119188-33-9 分⼦式: C₂₀H₂₈O₂ 分⼦量: 300.44 作⽤靶点: mTOR; Ribosomal S6 Kinase (RSK) 作⽤通路: PI3K/Akt/mTOR; MAPK/ERK Pathway 储存⽅式: Please store the product under the recommended conditions in the Certificate of Analysis. BIOLOGICAL ACTIVITY ⽣物活性 Coronarin A 是⼀种具有⼝服活性的天然物，可抑制 mTORC1 和 S6K1 增加 IRS1 活性。Coronarin A 具有抗炎 活性，也可⽤于糖尿病的研究。 IC50 Target mTORC1 S6K1 体外研究 Coronarin A (3-30 μM; 4 or 12 h) stimulates glycogen synthesis through activating PI3K/Akt/GSK3β signaling and inhibits gluconeogenesis by activating ERK-dependent Wnt/β-catenin/TCF7L2 pathway in rat primary hepatocytes [1]. Coronarin A (1-30 μM; 4 h) increases tyrosine phosphorylation of IRS1 through inhibiting mTOR/S6K1 signaling [1]. Western Blot Analysis [1] Cell Line: Primary rat hepatocytes Concentration: 1, 3, 10 and 30 μM Incubation Time: 4 h Result: Increased the Akt and GSK3β phosphorylation dose-dependently. Dose-dependently stimulated the phosphorylation of both ERK1 and