Conantokin-T-DataSheet-生命科学试剂-MCE.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE Conantokin-T Cat. No.: HY-P1287 CAS No.: 127476-26-0 分⼦式: C₁₁₀H₁₇₅N₃₁O₄₅S 分⼦量: 2683.81 Sequence Shortening: GE-{Gla}-{Gla}-YQKML-{Gla}-NLR-{Gla}-AEVKKNA-NH2 作⽤靶点: iGluR 作⽤通路: Membrane Transporter/Ion Channel; Neuronal Signaling 储存⽅式: Please store the product under the recommended conditions in the Certificate of Analysis. BIOLOGICAL ACTIVITY ⽣物活性 Conantokin-T 是⼀种含有 γ-羧基⾕氨酸的 N-甲基-D-天冬氨酸 (NMDA) 拮抗肽，IC50 值为2 μM。 Conantokin-T 在中枢神经系统神经元中抑制 NMDA 受体介导的钙内流。Conantokin-T 可以从捕鱼锥蜗⽜ Conus tulipa 的毒液中纯化。 IC50 Target IC50: 2 μM (NMDA) [1] 体外研究 Conantokin-T produces a partial antagonism of NMDA receptor function with an IC50 value of 2 μM [1]. 体内研究 Conantokin-T induces sleep-like symptoms in young mice [1]. REFERENCES [1]. J A Haack, et al. Conantokin-T. A gamma-carboxyglutamate containing peptide with N-methyl-d-aspartate antagonist activity. J Biol Chem. 1990 Apr 15;265(11):6025-9. McePdfHeight Caution: Product has not been fully validated for medical applications.