Cortistatin-29-DataSheet-生命科学试剂-MCE.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE Cortistatin 29 Cat. No.: HY-P3618 分⼦式: C₁₆₁H₂₄₂N₄₆O₄₁S₂ 分⼦量: 3539.77 Sequence Shortening: {Glp}-ERPPLQQPPHRDKKPCKNFFWKTFSSCK 作⽤靶点: Somatostatin Receptor 作⽤通路: GPCR/G Protein; Neuronal Signaling 储存⽅式: Please store the product under the recommended conditions in the Certificate of Analysis. BIOLOGICAL ACTIVITY ⽣物活性 Cortistatin 29 是⼀种神经肽。Cortistatin 29 可减轻神经性疼痛。Cortistatin 29 以⾼亲和⼒结合所有⽣长抑素 (SS) 受体亚型，对 SSTR1、SSTR2、SSTR3、 SSTR4，SSTR5 的IC50 值分别为 2.8,7.1,0.2,3.0,13.7 nM。 Cortistatin 29 显⽰出抗纤维化作⽤ [1] [2] [3] [4]。 IC50 Target SSTR1 SSTR2 SSTR3 SSTR4 2.8 nM (IC50) 7.1 nM (IC50) 0.2 nM (IC50) 3.0 nM (IC50) SSTR5 13.7 nM (IC50) 体内研究 Cortistatin 29 (1-2 µg) alleviates chronic neuropathic pain in mouse [1]. Cortistatin 29 (1 nmol/mouse; i.p.; three times weekly) shows anti-fibrotic effects in mouse [4]. Animal Model: 20-24 g body weight, 8-12 weeks-old mice [1] Dosage: 1 µg in 20 µL for s.c.; 2 µg in 200 µL for i.p.; 20 ng in 10 µL for i.t. Administration: Every other day for 12 days Result: