干细胞研究及其应用.pptVIP

* Successful Trial of Gene Therapy in France Uses “Adult” Stem Cells Science 288, 669-672, April 28, 2000. French researchers recently reported what appears to be the first successful trial of human gene therapy, boosting the immune systems of two infants with severe combined immunodeficiency by injecting them with their own stem cells containing a normal copy of the gene that they lacked. Researchers removed stem cells from the infants’ bone marrow, added a working copy of the gene to the cells’ DNA, and injected the repaired stem cells back into the infants (8 and 11 months oldat the time of treatment) 第64页/共74页 * Adult Stem Cells Reverse Diabetes in Mice Nature Medicine 6, 278-282, March 2000 Researchers at the University of Florida announced in March that they have reversed diabetes in mice using adult pancreatic stem cells. The pancreatic stem cells were harvested from adult donors and grown in culture, where they formed small functional organs known as islets of Langerhans (the insulin- secreting parts of the pancreas.) The cells were then injected under the skin of the diabetic mice, where they began secreting insulin. Within 7-10 days, the mice were able to regulate the levels of glucose in their blood. . 第65页/共74页 * Bone Marrow Stem Cell Transplant Used to Treat Children with Cartilage Defect Nature Medicine 5, 309-313, March 1999 Bone marrow-derived stem cells have been used clinically to treat children with osteogenesis imperfecta, a condition that leads to multiple fractures, severe bony deformities, and considerably shortened stature. Three months after treatment, the three children showed changes indicating new dense bone formation. The report by researchers at St. Jude Children’s Hospital in Memphis indicates the promising possibility for treatment of this as well as similar stem cell disorders. 第66页/共74页 * Neural Stem Cells Able to Repair Damage Throughout Brain Sciences USA 96, 7029-7034, June 8, 1999 In stu